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Clinically Isolated Syndrome (CIS)

The first episode of neurological symptoms lasting at least 24 hours.

Clinically Isolated Syndrome is like MS in that it’s caused by damage to your nervous system, but it’s different from MS in that this damage only happens once. CIS is caused by damage to the covering of nerves in the central nervous system (CNS). The damage can occur in more than one place, often resulting in symptoms such as dizziness and bladder problems. CIS can also be the first sign of multiple sclerosis which can lead to clinically definite MS, if there is evidence of further damage in the central nervous system.

MS Trust. Clinically Isolated Syndrome (CIS). Available at: Accessed March 2020

UK | July 2020 | MUL20-C021